Molecular mechanism of anti-parasite response of midgut bacteria of vector insect

为了研究中肠环境中的反应机制，包括受居民微生物群影响的疟疾寄生虫，我们专注于中肠细菌种内变异，赋予蚊子疟疾寄生虫传播能力的多样性。从实验室饲养的蚊子中分离的粘质沙雷氏菌在其细胞和结构特征上表现出很大的表型变异。这种变化与其抑制蚊子中肠内疟原虫寄生虫发育的能力直接相关。这些发现表明，通过对蚊子中肠细菌的遗传操作来控制疟疾的策略。

To investigate the response mechanisms within the midgut environment, including those influenced by resident microbiota against malaria parasite, we focus on a midgut bacteria species intra-specific variation that confers diversity to the mosquito`s competency for malaria parasite transmission. Serratia marcescens isolated from laboratory-reared mosquitoes shows great phenotypic variation in its cellular and structural features. This variation is directly correlated with its ability to inhibit Plasmodium parasite development within the mosquito midgut. These findings indicated that strategies for controlling malaria through genetic manipulation of midgut bacteria within the mosquito.