Study of new broad spectrum of anti-parasitic agent and basis of molecular base of it

N-89对疟疾和血吸虫病的作用机制：(1)综合蛋白质组学分析，N-89改变了曼氏血吸虫共11种蛋白质。其中，N-89作用24小时后，副肌球蛋白降至对照组的30%。在本研究中，疟疾寄生虫和曼氏血吸虫与N-89在蛋白质组学上不是相似的靶分子，有必要进一步验证两种病原体的差异。(2)体内实验表明，N-89缩短了曼氏血吸虫的体长，减少了血吸虫的产生。(3)罗丹明-N-89加合物可能作用于寄生虫体内。

The mechanism of action of N-89 for malaria and schistosomiasis;(1) Total 11 of proteins were changed by N-89 in Schistosoma mansoniusing comprehensive proteomics. Among them, paramyosin was reduced to 30% of control after 24hr treatment with N-89. Malaria parasite and S. mansoniwere not similar target molecules in proteomics with N-89 in the study and it will be necessary to validate further the differences in both 2 pathogens.(2) Body length of S. mansoni was shorted by N-89 administration and production of hemozoin also decreased in vivo experiment.(3) Rhodamine-N-89 adducts will may act incorporated into the parasite body clearly.