Functional analysis of IFITM3 in neurodevelopmental impairments

干扰素诱导的跨膜蛋白3 （IFITM3）在中枢神经系统中的作用在很大程度上是未知的，尽管它在神经和神经精神疾病患者的大脑中表达增加。在本研究中，我们展示了IFITM3在发育早期多i: c诱导免疫攻击小鼠的长期神经元损伤中的作用。我们的研究结果表明，在发育早期通过激活先天免疫系统诱导星形胶质细胞中IFITM3的表达具有非细胞自主作用，影响随后的神经发育，通过损害星形胶质细胞的内吞作用导致神经病理损伤和脑功能障碍。

The role of interferon-induced transmembrane protein 3 (IFITM3) in the CNS is largely unknown, despite the fact that its expression is increased in the brains of patients with neurologic and neuropsychiatric diseases. In the present study we show the role of IFITM3 in long-lasting neuronal impairments in mice following polyI:C-induced immune challenge during the early stages of development. Our findings suggest that the induction of IFITM3 expression in astrocytes by the activation of the innate immune system during the early stages of development has non-cell autonomous effects that affect subsequent neurodevelopment, leading to neuropathological impairments and brain dysfunction, by impairing endocytosis in astrocytes.