RNA Biology for Stress Assessment and Prediction of Major Depression

这项研究项目旨在识别新的RNA标记，用于应激评估和预测严重抑郁障碍。我们报告了外周血中SMG-1的急性应激特异性选择性剪接(Neurosci Lett 2010)和慢性应激特异性GR-β亚型的减少(Stress 2011)。我们还研究了外周血中的应激反应microRNAs(MiRNAs)。我们报道了miR-16、miR-144和miR144*为急性应激反应miRNAs(Nuerosi Lett 2012)。我们还鉴定了7个miRNAs为慢性应激反应miRNAs。

This research project was designed to identify novel RNA markers for stress assessment and prediction of major depressive disorders. We reported acute stress-specific alternative splicing of SMG-1in peripheral blood (Neurosci Lett 2010) and chronic stress-specific reduction of a GR-beta isoform (Stress 2011). We also investigated stress-responsive microRNAs (miRNAs) in peripheral blood. We reported miR-16, miR-144, and miR144* as acute stress-responsive miRNAs (nuerosci Lett 2012).We also identified 7 miRNAs as chronic stress-responsive miRNAs.