Neural mechanisms of discrimination of natural sounds learned by guinea pigs in the competition-based training

本研究的目的是说明在条件反射到自然声音（脚步声，F音）后，整体激活模式的变化。我们的假设是，行为成就与皮层网络的变化有关。这在电压敏感染料光学成像中被揭示。竞争性训练，即多只动物一起训练，有助于动物比竞争对手更早获得奖励。影像学结果表明，未训练和训练的动物在F音刺激下的皮层激活没有明显差异。时间反转的F音，这是频谱相同，但从F音时间反转，导致减少峰值激活，无论是在幼稚和训练的动物，但在训练的动物减少得多。这些结果表明，皮质网络，这可能是占主导地位的调谐到F音抑制激活其临时修改的版本比相应的天真的网络更有效。

The current study is to illustrate changes in global activation pattern after conditioning to a natural sound (footstep, F sound). Our assumption is that behavioral achievement would be linked to changes in cortical network. This was revealed in the voltage sensitive dye optical imaging. Competitive training, in which multiple animals were trained together, facilitated animals to reach reward earlier than competitors. Imaging results showed that obvious differences in cortical activation have not been found between naive and trained animals with F sound. The time-reversed F sound, which is spectrally the same as but temporally reversed from F sound, resulted in reduced peak activation, both in naive and trained animals, but in much more reduction in trained animals. These results suggest that the cortical network which may have been dominantly tuned to F sound suppresses activation by its temporally-modified version more efficiently than the corresponding naive network.