Identification of essential molecules and elucidation of the mechanism for novel cancer immune evasion system: Research for biomarker for immunological response

我们首先发现在原肿瘤克隆中产生了一个具有免疫逃避潜能的新克隆，该克隆易受肿瘤相关抗原特异性T细胞反应的影响。这种肿瘤克隆的出现依赖于T细胞的反应。新发肿瘤细胞MHC I类、TRP2、Gp100、IFN-γ（包括对IFN-γ的功能性应答）和Fas的表达均无变化，但sytl2、GATA1和2的表达上调，NGFR的表达下调，提示这些分子可能是肿瘤免疫逃避的潜在生物标志物。

We firstly found that a new clone, which have acquired the immune evasion potentials, emerges from the original neoplastic clone, which is susceptible to the tumor associated antigens-specific T cell response. This emergence of neoplastic clone is dependent on the T cell response. The new neoplastic cells have no change in the expression of MHC class I, TRP2, Gp100, IFN-γ (including functional response to IFN-γ), and Fas, but upregulate the expressions of sytl2, GATA1 and 2, and downregulate NGFR, suggesting that the molecules may be potential biomarkers in the immune evasion of neoplasm.