Alteration of fucosylation and biomarker development in lung cancer

高表达的〓1-6 focusyltransferase（〓1-6 FucT）在腺癌中比在鳞状细胞癌中更常见，并且与腺癌的晚期pN状态相关。高〓1,6-FT表达与潜在的治愈性切除和pStage I腺癌的不利临床结果相关。这些发现表明，〓1,6- ft及其核心聚焦产物可能是治疗非小细胞肺癌，特别是腺癌的有希望的生物标志物和治疗靶点。

High 〓1-6 fucosyltransferase (〓1-6 FucT) expression is more frequently found in adenocarcinomas than squamous cell carcinomas, and is correlated with advanced pN status in adenocarcinomas. High 〓1,6-FT expression is associated with an unfavorable clinical outcome in potentially curatively resected and pStage I adenocarcinomas. These findings suggest that 〓1,6-FT and its core-fucosylated products could be promisingbiomarkers and therapeutic targets for NSCLCs, especially for adenocarcinomas.