Syntheses of apatite via Ca complexes of amino acids involved innon-collagen protein

用氨基酸钙配合物制备了低结晶度的磷灰石粉末。基质的强度、磷灰石的结晶度和分布影响以制备的磷灰石和生物可降解聚合物（PLGA）为材料的三维多孔支架的再生能力。水溶液包被法是近年来发展起来的一种新的制备磷灰石的方法。用ASC法研究了骨钙素在具有特征性网状结构的磷灰石膜上的细胞粘附和膨胀。在此基础上，首次实现了在明胶中直接沉积磷灰石，通过非胶原蛋白中的氨基酸复合物来制备支架。

The apatite powders having low crystallinity were prepared using Ca complexes of amino acid ligands. The strength of the matrix, apatite crystallinity and distribution affected the regeneration ability of the 3 dimensional porous scaffolds with the prepared apatites and a biodegradable polymer (PLGA). The aqueous-solution coating (ASC) method was newly developed to afford a position and shape model of apatite in scaffolds. The cell attachment and expansion of osteocalcin on the apatite f ilms having characteristic network structure by ASC method were also examined. Based on theseresults, scaffold fabrication by apatite deposition directly in gelatin was newly achieved through the complexes of amino acids involved in non-collagen protein.