Synthetic and Structural Studies on Bioactive Natural Products

对具有生物活性的天然产物进行了合成研究，以确定它们的立体化学。通过串联自由基环化反应，高效地合成了一种新的抑制幽门螺杆菌生长的倍半萜。通过合成可能的立体异构体确定了托伐内酯A的立体化学结构，并考察了合成异构体的细胞毒性。关于新型抗真菌药物马胡索酸，建立了一种制备手性构筑块的新方法。

Synthetic studies on bioactive natural products, which could be new drugs, were carried out in order to determine their stereochemistry. A new sesquiterpene, potent inhibitor of H. pylori growth, was efficiently synthesized as a racemate via tandem radical cyclization. The stereochemistry of topsentolide A was determined by synthesis of their possible stereoisomers, and cytotoxicity of the synthetic isomers was examined. About Majusculoic acid, a novel antifungal drug, new method to prepare the chiral building block was established.