Sudden coronary death, pokkuri disease, and lipoprotein-associated sphingosine 1-phosphate

我们提出，在无冠状动脉粥样硬化的年轻患者中，富含脂蛋白酰亚胺的脂蛋白残余物与冠状动脉猝死的风险相关。然而，目前尚不清楚残留物如何参与冠状动脉猝死。在目前的研究中，我们试图将鞘氨醇1-磷酸（S1 P），这是集中在脂蛋白，载脂蛋白M，S1 P结合载脂蛋白，猝死。我们新的检测S1 P的方法允许测量血清中低浓度的S1 P;然而，正常和猝死患者之间的S1 P水平存在任何显著差异。我们现在关注的是抗apoA-I和抗apoM抗体在二维电泳图谱上的差异。

We have proposed that triglyceride-rich lipoprotein remnants are associated with the risk of sudden coronary death in younger cases without coronary atherosclerosis. However, it remains unclear how remnants are involved in coronary sudden death. In the present study, we tried to relate sphingosine1-phosphate (S1P), which is concentrated in lipoproteins, and apolipoprotein M, an S1P binding apolipoprotein, to sudden death. Our new assay method to detect S1P allowed to measure a low concentration of S1P in serum; however, there are any significant difference in S1P levels between normal and sudden death patients. We are now focusing on the difference in two dimensionalelectrophoresis pattern measured by anti-apoA-I and anti-apoM antidodies.