Effect on the suppression to diarrhea by hydrogen derived from the fermentation of intestinal microbes by the ingestion of nondigestible oligosaccharide.

非病理性腹泻多由肠内营养和抗生素治疗引起。我们已经阐明，渗透性腹泻的诱导是通过摄入不可消化的低聚糖来抑制的。在这项研究中，我们利用诱发腹泻的模型动物，研究了低聚果糖对腹泻的抑制作用和肠道菌群变化之间的相互作用。提示高氢气排泄量、较高水平的氧化应激标志物、炎性细胞因子和较低的肠道微生物来源的有害酶活性相互作用，对腹泻有抑制作用。我们相信，不可消化的糖类可以为改善液体配方做出贡献。

Non-pathogenic diarrhea is often induced by the enteral nutrition and antibiotic treatment. We have already clarified that the induction of osmotic diarrhea was suppressed by the ingestion of nondigestible oligosaccharide. In this study we examined the interaction among the suppression to diarrhea and the change in intestinal microflora by the ingestion of fructooligosaccharide using modeled animals that induce the diarrhea. It was suggested that the suppression for diarrhea interacted among the higher excretion of hydrogen gas, the better levels of oxidative stress markers, inflammatory cytokines, and lower activities of harmful enzymes derived from intestinal microbes. We believe that the nondigestible saccharides can contribute the improvement of the liquid formula.