The relationship between chronic injury and the origin of the liver tumor analyzed using mouse model

我们通过在白蛋白启动子下诱导活化的Kras表达和抑制Pten的表达来建立小鼠肝癌模型。小鼠在7 ~ 8周死于多发性肝癌。通过SNP芯片的基因组分析，我们发现Hippo通路是一种新的细胞内信号通路，参与了肝癌的发生。SAV 1的畸变，途径的一个组成部分，被证明诱导激活雅普/TAZ和随后的表达CTGF在肝癌细胞系。

We generated hepatic cancer mouse model by inducing expression of activated Kras and ablation of Pten under albumin-promoter. The mice died from multipe liver tumor in 7 to 8 weeks. Using genomic analysis of SNP array, we found that Hippo pathway, a novel intracellular signaling, was involved in hepatocarcinogenesis. Aberration of SAV1, a component of the pathway, was shown to induce the activation of YAP/TAZ and following expression of CTGF in a liver cancer cell line.