Circulating tumor cell-based tailor-made therapy for hepatocellular carcinoma

我们用一种新的方法“TelomeScan”检测了肝细胞癌患者外周血中的端粒酶阳性细胞。我们证实，我们检测到的大多数细胞是循环中的肿瘤细胞，这是一个有希望的转移标志。有趣的是，我们甚至在早期阶段就检测到了这些细胞，这表明需要另一个因素来形成转移灶。我们无法完全克服假阳性和假阴性的问题，今后必须解决这些问题。

We detected telomerase-positive cells in the peripheral blood of hepatocellular carcinoma using a new method “TelomeScan”. We confirmed that most of the cells we detected were circulating tumor cells, which was a promising marker of metastasis. Interestingly, we detected the cells even in early stages, indicating another factor is needed to form metastatic lesions. We could not completely overcome the problems of false-positive and false negative and they must be addressed in the future.