A New Strategy for the prevention of vascular aging in subjects with metabolic syndrome

在本研究中，男性和女性的白细胞端粒长度(LTL)与年龄呈负相关，(2)与BaPWV和径向增大指数(AI)等血管僵硬指标无关，(3)与内皮功能无关，(4)与血肌酐水平呈负相关。当按性别分析时，它只在女性中有意义。尽管在流行病学研究中已有报道表明LTL与动脉粥样硬化性疾病有关，但在我们的心血管疾病受试者中并未出现这种情况。LTL与年龄显著相关，LTL不能反映血管老化状态。然而，LTL可能是日本门诊患者肾脏老化的一个标志。

In this study, leukocyte telomere length (LTL) was:(1)Inversely associated with chronological age both in men and women.(2)Not associated with vascular stiffness markers such as baPWV and radial augmentation index (AI).(3)Not associated with endothelial function.(4)Inversely associated with serum creatinine level. When analyzed by gender, it was significant only in women.Although LTL has been reported to be associated with atherosclerotic diseases in epidemiological studies, that was not reproduced in our subjects with cardiovascular diseases. LTL was significantly associated with chronological age, LTL did not reflect the status of vascular aging. However, LTL could be a marker of kidney aging in out Japanese patients.