Evaluation of gene-environment interaction in development of chronic kidney disease and cardio-vascular disease
Evaluation of gene-environment interaction in development of chronic kidney disease and cardio-vascular disease
批准号:
22590888
负责人:
HAYASHI Mutsuharu
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们采集了公司过去几年的50,000多份体检数据,医疗保健信息,包括环境参数(吸烟、餐饮口味、锻炼习惯),同时进行DNA提取,与约1,200人进行SNPs分析,达成协议,公司和员工的合作。我们开发了一种针对代谢综合征和糖尿病的SNP提示,并提取了疾病组和对照组,并进行了SNP分析。利用生物信息学软件的新发展,我进行了SNP和血液检测,结合环境参数分析,确定了一个关于代谢综合征、糖尿病发病和进展风险的新组合。
英文摘要
We acquired the company medical examination data for the past several years more than 50,000, medical careinformation including the environmental parameter (smoking, meal taste, exercise customs) at the same time to perform DNA extraction, the SNPs analysis of approximately 1,200 people with an agreement, the cooperation of a company and the employee. We developed an SNP tip for metabolic syndrome and diabetes and extracted disease group and a control group and performed SNP analysis. Using bioinformatics software of the new development, I performed SNP and a blood test, combination of environmental parameter analysis and identified a new combination about a risk about metabolic syndrome, diabetes onset and progression.
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DOI:
10.1159/000345483
发表时间:
2012-01
期刊:
Nephron extra
影响因子:
--
作者:
[Okumura N, Hayashi M, Imai E, Ishii H, Yoshikawa D, Yasuda Y, Goto M, Matsuo S, Oiso Y, Murohara T]
通讯作者:
Murohara T
DOI:
10.1007/s10157-011-0523-0
发表时间:
2011-12-01
期刊:
CLINICAL AND EXPERIMENTAL NEPHROLOGY
影响因子:
2.3
作者:
[Imai, Enyu, Yasuda, Yoshinari, Matsuo, Seiichi]
通讯作者:
Matsuo, Seiichi
DOI:
10.1016/j.thromres.2011.07.013
发表时间:
2011-12-01
期刊:
THROMBOSIS RESEARCH
影响因子:
7.5
作者:
[Hayashi, Mutsuharu, Takeshita, Kyosuke, Murohara, Toyoaki]
通讯作者:
Murohara, Toyoaki
Impact of Indoxyl Sulfate on the Progression of Endothelial Dysfunction and Atherosclerosis in Chronic Kidney Disease Patients
硫酸吲哚酚对慢性肾病患者内皮功能障碍和动脉粥样硬化进展的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Mutsuharu Hayashi, Hideki Ishii, Daiji Yoshikawa, Akihiro Hirashiki, Takahiro Okumura, Toyoaki Murohara]
通讯作者:
Toyoaki Murohara
Brain Natriuretic Peptide as a Novel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction
脑利钠肽作为无心脏功能障碍的慢性肾病患者盐敏感性的新标志物
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Mutsuharu Hayashi, Yoshinari Yasuda, Hideki Ishii, Daiji Yoshikawa, Toyoaki Murohara]
通讯作者:
Toyoaki Murohara
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