evelopment ofprognostic models for predicting the outcome of cutaneous T-cell lymphomas based on biological prognostic factors

为了建立一个预测原发性“皮肤型”ATL预后的模型，分析了有皮肤病变的郁积型ATL患者的预后因素。多变量分析中，总生存率差的独立预后因素为较高的年龄、高血清LDH和较高的可溶性IL-2受体水平，而红皮病和肿瘤细胞上CXCR 3表达与良好的生存率相关。高血清LDH和高可溶性IL-2受体水平也与ATL急性危象或死亡的高风险相关。红皮病或CXCR 3/T-bet表达肿瘤细胞的患者疾病进展风险较低。

To develop a prognostic model for predicting the outcome of primary 'cutaneous-type' ATL, prognostic factors in the smoldering-type ATL patients with cutaneous lesions were analyzed. Independent prognostic factors for poor overall survival in multivariate analyses were higher age, high serum LDH, and higher soluble IL-2 receptor levels, while erythroderma and CXCR3 expression on tumor cells were associated with good survival. High serum LDH and higher soluble IL-2 receptor levels were also associated with higher risk for acute crisis or death from ATL. Patients with erythroderma or CXCR3-/T-bet-expressing tumor cells had lower risk for disease progression.