Iintervention and discrimination of developmental disorders and prodromal state of psychosis in adolescents by biological methods

本文对74例12-18岁精神病前驱状态（高危精神状态）患者进行了调查。74例ARMS患者中，虽然有59%符合广泛性发育障碍（PDD）的诊断标准，但PDD组与非PDD组向精神分裂症的转化率无差异。在认知功能检查中，40例ARMS患者的BACS-J评分中，过渡组的语言记忆（p< 0.05）、注意（p< 0.005）和总分（p<0.05）均显著下降。对90例ARMS患者的SIPS评分进行Logistic回归分析。优势比为1.898（p< 0.05）P1;思想/妄想的非自然内容，0.411（p< 0.05）在P3、夸大的想法和4.203 P_4组（p< 0.01）;意识/幻觉异常越多，P1、P4分值越高，就越会带来一个发病可能性越来越大的结果。在生物学指标中，正在分析BDNF、EDA和microRNA。由于（3）和（4）的患者同意量很少，因此正在继续研究。

Seventy four 12-18-year-old patients with prodromal state of psychosis (At Risk Mental State : ARMS) were investigated. 23% patients shifted to schizophrenia in observation 12 months after diagnosing as the risk state,.Although 59% among 74 ARMS patients met the diagnostic criteria of pervasive developmental disorder (PDD), there was no difference in the transition rate to schizophrenia between PDD group and non-PDD group. Moreover, in the cognitive function inspection, BACS-J of forty ARMS patients, the transition group accepted the significant fall in the item of language memory (p< 0.05), cautions (p< 0.005), and Total score (p<0.05), respectively. Further, logistic regression analysis was performed for 90 ARMS patients' SIPS score. The odds ratio was 1.898 (p< 0.05) in P1; the unnatural content of thought / delusion, 0.411 (p< 0.05) in P3; the exaggerated idea and 4.203 (p< 0.01) in P4; the abnormalities of the consciousness / hallucination, and the more the score of P1 and P4 went up, the more a result with the increasing possibility of the onset of a disease was brought. In a biological index, it is under analysis about BDNF, EDA, and a micro RNA.Since there is little consent patient load about (3) and (4), research is under continuation.