Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy

我们进行了针对放射治疗后高级脑功能障碍的临床试验。其中4例纳入本研究。其中胶质母细胞瘤1例，低级别胶质瘤1例，中枢神经系统淋巴瘤1例，脑转移瘤1例。男3例，女1例。他们的年龄分别为30岁、67岁、72岁。照射野设为全脑照射2例，局部照射2例。照射剂量30~60Gy.所有病例均观察盐酸多奈哌齐的疗效。无2级以上并发症发生。综上所述，盐酸多奈哌齐似乎是治疗放射治疗后较高的脑功能障碍的有效和安全的治疗方案。

We peformed clinical trials against higher brain dysfunction after radiation therapy. Among this period, 4 cases were enrolled in this study. There were a patient with glioblastoma, a patient with low grade glioma, a patients with CNS lymphoma, and a patient with metastatic brain tumor. There were 3 male and 1 female patients. They were 30, 67, 72 years old, respectively. Radiation fields were set as whole brain irradiation in 2 patients, and localized fields in other 2 patients. Radiation doses were ranging from 30-60 Gy. Efficacy of donepezil HCl were observed in all cases. There were no case who experienced more than Grade 2 morbidity. In conclusion, donepezil HCl seemed to be effective and safe treatment option against higher brain dysfunction after radiation therapy