Basic research about leg dysfunction in spina bifida

本研究建立了手术诱导的雏鸡SBA模型。(2)组织学分析显示，SBA雏鸡的中间神经元比正常雏鸡少，但运动神经元的数量没有观察到差异。(3)SBA雏鸡早期发育阶段多余运动神经元的产生和消除缺陷可能与该疾病运动并发症的病理机制有关。(4)孵化出的SBA雏鸡背索比正常对照雏鸡小。在SBA雏鸡的所有索中均观察到变性的感觉神经纤维。(5)在SBA雏鸡中显示出突触发生和组织成熟的延迟。

We developed surgery-induced chick SBA(1) SBA chicks exhibited leg muscle paralysis.(2) Histological analyses revealed fewer interneurons in SBA chicks than in normal chicks, but no difference was observed in the number of motor neurons.(3) a defect in the production and elimination of excess motor neurons during the early developmental stages in SBA chicks may be involved in the pathological mechanism of the motor complications of this disease.(4) The dorsal funiculus was smaller in hatched SBA chicks than in the normal controls. Degenerated sensory nerve fibers were observed in all funiculi of SBA chicks.(5) Delay in synaptogenesis and tissue maturation in SBA chicks was shown.