Development of novel physicochemical and molecular biological therapy for the metastatic bone tumors

我们开发了新型的转移性骨肿瘤的物理化学和分子生物学治疗方法。首先，我们证明了核因子-kappaB诱饵通过抑制VCM-1和ICAM-1的表达，抑制了乳腺癌细胞系在骨转移部位的细胞侵袭和细胞生长。其次，我们演示了纳米磁性粒子高温处理策略的效果。第三，使用吖啶橙的光动力疗法(PDT)被证明不仅对肉瘤有效，而且对转移性骨肿瘤也有效。实际上，我们已经开始了PDT在骨转移瘤的临床应用。最后，我们开发了射频消融(RFA)联合热敏脂质体包埋阿霉素的方法，以期安全、有效地治疗脊柱转移瘤。有必要进行进一步调查。

We developed the novel physicochemical and molecular biological therapy for the metastatic bone tumors. First, we showed that NF-kappaB decoy suppress the cell invasion and cell growth of breast cancer cell line at the bone metastatic site, by inhibiting the expression of VCM-1and ICAM-1. Second, we demonstrated the effect of hyperthermic treatment strategy with magnetic nano-particle. Third, Photodynamic therapy(PDT) using acridine orange is proved to be effective treatment not only for the sarcoma, but also for metastatic bone tumors. Actually we started clinical application of PDT for the bone metastases. Finally, we developed the radiofrequency ablation (RFA) combined with thermo-sensitive liposome-embedding doxorubicin in an effort to safe and effective RFA treatment for the metastatic spinal tumor. Further investigation is necessary.