The mechanisms of immunosuppression and organ dysfunctions following surgical stress and its modulation.

本研究旨在探讨手术应激引起免疫抑制和器官功能障碍的机制及其调控策略。创伤-出血（T-H）后，血浆TNF-α、IL-6和HMGB 1水平升高。血浆AST和ALT浓度也在T-H后升高。血栓调节蛋白（TM）处理改善了血浆细胞因子和HMGB 1浓度。肝损伤也有所改善。TM可能是手术应激患者的有益治疗。

The purposes of this study were to investigate the mechanisms of surgical stress induced immunosupPression and organ dysfunction and to develop the strategy of its regulation. After trauma-hemorrhage (T-H), plasma levels of TNF-α, IL-6, and HMGBl increased. Plasma AST and ALT concentrations also increased after T-H. Thrombomodulin (TM) treated improved plasma cytokines and HMGBl concentrations. Liver injury also improved. TM may be a beneficial treatment for surgical stressed patients.