Optimization of loading superabsorbent polymer microspheres with anticancer drugs for use in chemoembolization of liver tumors unresponsive to standard therapy

本研究的目的是优化制备高吸水性聚合物(SAP)微球作为一种有效的药物输送系统，用于临床上对标准治疗无效的肝肿瘤的化疗栓塞术。含碘造影剂、非离子等渗碘造影剂和静脉滴注伊立替康溶液分别适合作为载药顺铂、表阿霉素和伊立替康微球的溶剂。在兔肝VX2移植瘤模型上的体内研究结果表明，抗癌药物SAP微球化疗栓塞术更有效地抑制了肿瘤的生长。

The purpose of this study was to optimize the preparation for loading superabsorbent polymer (SAP) microspheres with anticancer drugs as an efficient drug delivery system for use in chemoembolization of liver tumors unresponsive to standard therapy in clinical practice. Iodinated contrast medium, nonionic isosmotic iodinated contrast medium and undiluted irinotecan solutions for intravenous drip infusion were most suitable for solvent in loading SAP microspheres with cisplatin, epirubicin and irinotecan, respectively. This result of in vivo study in a rabbit model with transplanted liver VX2 tumors suggested that chemoembolization with anticancer drug-loaded SAP microspheres was more effective in suppressing the tumor growth.