Treatment of malignant glioma with Olig-1 and Olig2

胶质瘤是一种起源于神经胶质细胞的颅内原发恶性肿瘤。OLIG2是一种转录因子，在神经胶质前体细胞中表达，在向少突胶质细胞分化过程中发挥作用。在恶性星形细胞瘤，即胶质母细胞瘤(GBM)和间变性星形细胞瘤(AA)中也有表达。因此，本研究对胶质瘤组织中的寡核苷酸2的表达进行了详细的分析，并探讨了其与恶性胶质瘤预后的关系。(结果)共检测118例恶性胶质瘤(基底细胞瘤43例，再生障碍性胶质瘤75例)。这些患者是在1987至2007年间接受治疗的。GbM和AA的Orig2平均阳性率分别为16%和45%。在GBM中，Opol2阳性率与预后无相关性。另一方面，在再生障碍性贫血中，低聚合子2的高阳性率(40%)与较长的生存期有关。这种相关性具有统计学意义。(对数等级检验：P=0。结论：我们观察到AAA患者的Opol2阳性率与患者的生存时间相关。这些结果表明，在胶质瘤细胞中诱导寡核苷酸可改善再障患者的预后。

Gliomas are primary intracranial malignant tumors derived from glial cells. Olig2 is a transcriptional factor which is expressed in glial precursor cells and functions in the differentiation to oligodendrocyte. Also, Olig2 is expressed in malignant astrocytoma, i. e. glioblastoma(GBM) and anaplastic astrocytoma(AA). Therefore, I analyzed the Olig2 expression in GBM and AA in detail and examined the association between Olig2 expressionn and prognosis of malignant gliomas.(Results) Total of 118 malignant gliomas were examined(GBM : 43 cases, AA : 75 cases). The patients were treated between 1987 and 2007. Mean Olig2 positive rate was 16% in GBM and 45% in AA. In GBM, there was not the association between Olig2 positive rate and prognosis. On the other hand, in AA, high positive rate of Olig2(> 40%) associated with longer survival. This association was statistically significant.(Log rank test : p=0. 0048)(Conclusion) We observed correlation between Olig2 positive rates and survival in AA patients. These results indicate that the induction of Olig2 in glioma cells would improve the prognosis in AA patients.