Research of signaling mechanism in nasopharyngeal cancer

特殊at -富结合蛋白1 （SATB1）是染色质重塑和基因表达的全球调节剂，与促进多种癌症的生长和转移有关。本研究表明，eb病毒（EBV）的主要致癌基因潜伏膜蛋白1 （latent membrane protein 1, LMP1）可上调人鼻咽细胞系SATB1 RNA和蛋白的表达。我们发现，在鼻咽癌（NPC）患者的组织样本中，SATB1蛋白水平升高。综上所述，我们的研究结果表明SATB1在ebv阳性鼻咽癌中作为LMP1信号传导的前转移效应物起作用。

A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines.We show that SATB1 protein levels are elevated in tissue samplesfrom patients with nasopharyngeal carcinoma (NPC). Taken together, our results suggest that SATB1 functions as a prometastatic effector of LMP1 signalling in EBV-positive NPC.