Roles and modes of nectins in the development and regeneration of the olfactory epithelium

嗅觉上皮是一种特殊的感觉上皮，位于鼻腔内。在本研究中，我们观察了发育中的小鼠嗅觉上皮中支持细胞和嗅觉细胞的细胞排列。我们发现，在嗅上皮的顶端细胞-细胞接触部位，蜜腺蛋白以不同和互补的方式分布。我们研究了表达不同黏附分子的细胞的混合培养实验的效果。根据黏附分子的不同，形成了不同的细胞排列。因此，我们揭示了果胶的相互作用与嗅上皮细胞的这些重排有关。

The olfactory epithelium, which is located inside the nasal cavity, is a specialized sensory epithelium. In this study, we observed the cellular arrangements of supporting cells and olfactory cells in the developing mouse olfactory epithelium. We found that nectins were distributed in differential and complementary patterns in the apical cell-cell contact sites of the olfactory epithelium. We investigated the effect of a mixed culture experiment of the cells expressing differential adhesion molecules. Various cellular arrangements were formed depending on the adhesion molecules. Thus, we revealed that interactions of nectins are implicated in these cellular rearrangements in the olfactory epithlium.