Analysis of the molecular mechanism of CD44-mediated glucose metabolism in cancer cells for the development of new cancer therapy

为了研究CD44介导的葡萄糖代谢调节是否可以成为癌症治疗的新靶点，我们研究了CD44表达对糖酵解关键酶PKM 2活性的影响。PKM2与CD44相互作用，这种相互作用增加了PKM2的酪氨酸磷酸化，导致癌细胞糖酵解表型的增强。因此，发现CD44介导的糖酵解途径的调节是癌症治疗的新分子靶点。

To examine whether the CD44-mediated modulation of glucose metabolism could be a new target for cancer therapy, we investigated the effect of CD44 expression on the activity of PKM2, a key enzyme for glycolysis. PKM2 was interacted with CD44 and such interaction increased the tyrosine phosphorylation of PKM2 leading to the augmentation of the glycolytic phenotype of cancer cells. Thus, CD44-mediated modulation of glycolysis pathway was found to be a new molecular target for cancer therapy.