Analysis of the distribution of cohesin in human oocytes to figure out the mechanism of age-related increase of chromosomal nondisjunction.

在人类中，卵母细胞中与年龄相关的非整倍性增加被认为是出生患有唐氏综合征或流产的后代的原因之一。有人认为，在减数分裂中参与染色体分离的分子，即粘着蛋白的减少导致了非整倍体。在这项研究中，我询问了在老年人卵母细胞中粘附素的量是否真的减少了，并表明在老年妇女中可以检测到卵母细胞的粘附素。然而，由于目前没有足够的样本，年龄之间的比较尚未进行。

In humans, age-related increase of aneuploidy in oocytes is known as one of the causes of the birth of offspring with Down's syndrome or miscarriage. It has been suggested that the decrease of the molecules, cohesins, involving chromosome segregation in meiosis contributes aneuploidy. In this study, I asked whether the amount of cohesins has actually decreased in aged human oocytes, and showed that the cohesins of oocytes could be detected in aged women. However, the comparison between ages has not yet proceeded because of the unavailability of enough samples at this time.