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Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration

Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration
新型细胞因子IL-17诱发慢性扁桃体炎发病的分子机制 振动直接驱动鼓膜助听器的开发
批准号:
22591921
负责人:
ICHIHARI Yukiko
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
我们证实了IL-17与慢性扁桃体炎、扁桃体肥大和病灶感染的相关性。利用扁桃体淋巴细胞和外周血淋巴细胞,采用流式细胞术(FACS)和Western blotting检测IL-17蛋白的表达。不同疾病中IL-17的定位和表达不同。美洲商陆丝裂原刺激扁桃体组织内的B细胞产生IL-17抗体。
英文摘要
We demonstrated the relevance of IL-17 to chronic tonsillitis, tonsillar hypertrophy, and focus infection. The expression of IL-17 protein was investigated by FACS and Western blotting using tonsillar lymphocytes and peripheral blood lymphocytes. The localization and expression of IL-17 was differed among several disorders. The B cells inside tonsillar tissues stimulated by pokeweed mitogen resulted in a significant contribution to production of IL-17 antibodies.
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DOI: 10.1093/ndt/gfr403
发表时间: 2012-03-01
期刊: NEPHROLOGY DIALYSIS TRANSPLANTATION
影响因子: 6.1
作者: [Sato, Daisuke, Suzuki, Yusuke, Tomino, Yasuhiko]
通讯作者: Tomino, Yasuhiko
海外基金