Development and the clinical application of the bioabsorbed mesh onplant system for orthodontic anchorage

本研究的目的是研制一种新型的正畸支抗生物吸收网状种植体系统。将脱矿牙本质基质(DDM)作为一种有机材料植入大鼠颅骨缺损区，观察其骨再生能力，并探讨其作为骨替代材料的可行性。总之，DDM可能是一种有用的骨替代物，通过在手术后不久诱导高水平的新骨形成，作为骨再生的支架。第二项研究的目的是确定Reveromucin A(RMA)对OPG-/-小鼠骨吸收的抑制作用。这些数据表明，RMA可使OPG-/-小鼠在持续移动过程中的骨代谢和牙槽骨丢失恢复正常。本研究认为RMA有可能作为一种生物吸收材料植入种植系统。

The purpose of this study is to development new bioabsorbed mesh onplant system for orthodontic anchorage. Demineralized dentin matrix (DDM), an organic material derived from the dentine of bovine teeth, was grafted in rat skull defects to determine its bone regeneration ability and the possibility of its use as a bone substitute for bioabsorbed mesh onplant system. In conclusion, DDM may be a useful bone substitute that serves as a scaffold for bone regeneration by inducing a high level of new bone formation soon after surgery. The purpose of the second study was to identify the effect of Reveromucin A (RMA) on inhibiting bone resorption in OPG-/- mice. These data was suggested that RMA normalizes bone metabolism and loss of alveolar bone during continuous tooth movement in OPG-/- mice.This study concluded that RMA has possibility of the bioabsorbed mesh onplant system.