Hierarchical Study on Protein Functional Mechanism

在一般的蛋白质工程研究的生物分子的功能机制，实验使用湿材料和信息学使用干计算机独立进行。然而，要突破蛋白质功能机制的认识，必须将实验与信息学方法联合收割机协同应用。本研究以噬菌体展示技术为实验手段，以优化方法为信息学手段，发现了能够抑制淀粉样β蛋白原纤化和可溶性寡聚体形成的新型短肽和小分子化合物。

In general protein engineering studies for functional mechanism of biomolecules, experiments using wet materials and informatics using dry computers are independently performed. However, it will be necessary for breakthrough of understanding of protein functional mechanisms to combine the experiments with the informatics methods synergistically. In this study, by using a phage display method as an experiment and an optimization method as informatics, novel short peptides and a small compound were found to inhibit fibrillation and soluble oligomer formation of amyloidβprotein.