Translational Study For Child Abuse using Mice As Its Animal Model
Translational Study For Child Abuse using Mice As Its Animal Model
批准号:
22658093
负责人:
EBIHARA Shizufumi
金额:
$2.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
本研究旨在从行为学的角度评价Usp46突变小鼠作为人类虐待儿童动物模型的有效性(Usp46调节小鼠的“行为绝望”)。我们考察了人类虐待儿童的三个特征:(1)反复虐待,(2)下一代继承虐待儿童,(3)压力诱导的虐待儿童。结果,我们发现Usp46突变小鼠具有这三个特征。
英文摘要
The present study was undertaken to assess the validity of Usp46 mutant mice from behavioral standpoint as an animal model for child abuse in human(Usp46 regulates "behavioral despair" in mice). We examined three features in human child abuse :(1) repetition of abuse,(2) succession of child abuse to next generation,(3) stress-induced child abuse. As a result, we found that Usp46 mutant mice possess these three features.
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マウスの"行動的絶望"を制御する遺伝子Usp46の特定
鉴定出控制小鼠“行为绝望”的基因 Usp46
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Katata, G., Kajino, M., Hiraki, T., Aikawa, M., Kobayashi, T., Nagai, H., 海老原史樹文]
通讯作者:
海老原史樹文
DOI:
--
发表时间:
2010-02
期刊:
Japanese journal of psychopharmacology
影响因子:
--
作者:
[S. Ebihara;Shigeru Tomida]
通讯作者:
S. Ebihara;Shigeru Tomida
Deubiquitination and behavior
去泛素化和行为
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[K.Muroda, K.Nakashima, M.Shibata, M.Demura, H.Kandori, 海老原史樹文]
通讯作者:
海老原史樹文
DOI:
10.1371/journal.pone.0039084
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Imai S, Mamiya T, Tsukada A, Sakai Y, Mouri A, Nabeshima T, Ebihara S]
通讯作者:
Ebihara S
時間生物学
时间生物学
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Nakagawa A., et al., 寺田晃士, 内匠透]
通讯作者:
内匠透
共 8 条
An approach to mental disorders using model mice
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批准号:22248033
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$29.87万
-
财政年份:2010
-
负责人:EBIHARA Shizufumi
-
依托单位:
Molecular Mechanisms of Vertebrate Photoperiodism
-
批准号:17108003
-
项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$71.55万
-
财政年份:2005
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负责人:EBIHARA Shizufumi
-
依托单位:
CLONING OF AVIAN CLOCK GENES AND ANALYSIS OF CIRCADIAN CLOCK AND PHOTOTERIODIC TIME MEASUREMENT
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批准号:12460123
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
-
财政年份:2000
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负责人:EBIHARA Shizufumi
-
依托单位:
Genetic and Physiological Studies of Circadian Mutant Mice
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批准号:10460130
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.46万
-
财政年份:1998
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负责人:EBIHARA Shizufumi
-
依托单位:
Molecular and Cellular Mechanisms of Biological Rhythms
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批准号:09044216
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.63万
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财政年份:1997
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负责人:EBIHARA Shizufumi
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依托单位:
CHEMICAL MUTAGENESIS IN MOUSE CIRCADIAN RHYTHMS
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批准号:07557187
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$1.6万
-
财政年份:1995
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负责人:EBIHARA Shizufumi
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依托单位:
Cyourui saakadian rizumu no shinnke naibunnpitsu kikou
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批准号:03660279
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
-
财政年份:1991
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负责人:EBIHARA Shizufumi
-
依托单位:
海外基金