Development of the tools for organ stress and its surgical application

脂肪肝对各种外科手术非常敏感，与术后肝衰竭、再生受损、术后感染和败血症有关。在本研究中，我们采用新开发的光学探针进行生物成像，分析手术应激对术后肝功能、损伤和脂肪变性肝再生的影响。我们对小鼠肝脏进行了连续无创评估，并分析了术后肝损伤和再生受损的潜在机制。

Steatotic liver, very sensitive to various surgical procedures, is associated with post-operative liver failure, impaired regeneration, post-operative infection and sepsis. In the present study, we analyzed whether the surgical stress affects the post-operativeliver function, injury and regeneration of steatotic liver by newly developed optic probes for bio-imaging. We evaluated mouse liver continuously and non-invasively and analyzed the underlying mechanism of post-operative liver injury and impaired regeneration.