Development ofa new probe for dynamic imaging of transplanted cells without surgical operation.

本研究构建了一种可用于荧光、化学发光和磁共振成像的新型探针，并对其进行了评价。荧光蛋白与化学发光蛋白的融合和铁蛋白作为铁指示剂，使移植细胞能够在体内进行示踪。由于新的具有三种功能的探针工作良好，我们正在准备以荧光蛋白的金星为表达标记，荧光素酶为活细胞标记，铁蛋白为MRI标记的新的活体成像方法。

A new probe which detectable for fluorescence, chemiluminescence and magnetic resonance (MR) imaging was constructed and evaluated in this study. The fusion of a fluorescent protein to a chemiluminescent protein and ferritin as iron indicator has enabled to pursue the transplanted cells at in vivo. Since the novel probe which possess three kinds of function have worked well, we are preparing the new publication of the novel in vivoimaging method using Venus of fluorescent protein as expression marker, luciferase as live cell marker and ferritin protein as MRI marker.