Study of novel lipid-lowering effects of sesaminol, a sesame lignan

芝麻胺醇是芝麻木质素，并且在芝麻种子中最专门地以芝麻胺醇三葡糖苷存在。在这项研究中，芝麻酚苷元对脂质代谢的影响进行了研究在Sprague-Dawley大鼠。4周龄雄性大鼠饲喂含0~0。20%芝麻酚饲养4周后，测定血清和肝脏脂质水平。我们首次报道，膳食芝麻胺醇以剂量依赖性方式显著降低血清和肝脏脂质，尤其是甘油三酯水平;这种降低似乎大于其他众所周知的功能成分。导致观察到的甘油三酯浓度降低的机制可能是由于参与脂肪酸合成和氧化的酶活性的相互反应。

Sesaminol is a sesame lignin and is present most exclusively occurring as sesaminol triglucoside in sesame seed. In this study, effect of sesaminol aglycone on lipid metabolism was investigated in Sprague-Dawley rats. Four-week-old male rats were fed diets containing 0～ 0. 20% sesaminol. After 4 week-feeding period, serum and liver lipids levels were determined. We reported, for the first time, that dietary sesaminol significantly reduce(s) serum and hepatic lipids, especially triglyceride levels in a dose dependent manner ; this reduction appeared to be greater than those of a well-known other functional components. The mechanism responsible for the observed reduction in the concentration of triglyceride may be due to a reciprocal response in the enzyme activities involved in fatty acid synthesis and oxidation.