Development of the affinity matrix for comprehensive analysis of ligand- binding proteins

药物和毒素等生物活性化合物通常通过与其特定受体相互作用来显示其活性。在这项研究中，我们探索了全氟辛烷磺酸和芹菜素的结合蛋白，全氟辛烷磺酸是一种人造氟表面活性剂，也是一种全球性污染物，芹菜素是黄酮类的天然产物。我们还开发了一种新的亲和矩阵来纯化生物活性化合物的结合蛋白。

Bioactive compounds such as drugs and toxins generally show their activities by interacting with their specific receptors. In this study, we explored the binding proteins of perfluorooctanesulfonic acid, which is a man-made fluorosurfactant and global pollutant, and apigenin, which is a natural product belonging to the flavone. We also developed a novel affinity matrix for purifying the binding proteins of bioactive compounds.