Development of synthetic methods and functions of disubstituted hybrid calixarenes

综述了双取代杂杯[4]芳烃的合成方法和功能，即用配位功能基取代传统杯[4]芳烃的两个羟基。优化了Ullmann型胺化反应，在25位和27位引入膦酰基、膦酰基和碘代基团，并将碘代基团转化为羧基。进一步阐明了双膦衍生物与金属离子的独特配位方式，以及双膦酸对稀土金属离子的选择性萃取。

Development of the synthetic methods and functions of disubstituted hybrid calix[4]arenes, in which two hydroxy groups of conventional calix[4]arene are replaced with coordinative functional groups, have been examined. The optimization of Ullmann-type amination, introduction of phosphinoyl, phosphono, and iodo group at 25- and 27 positions and the conversion of iodo groups to carboxy groups were achieved. Furthermore, the elucidation of unique coordination manner of diphosphine derivative toward metal ions and the selective extraction of rare-earth metal ions by diphosphonic acid were achieved.