Nitrergic function in life style-related diseases

氮能神经扩张血管和阴茎海绵体平滑肌，分别在脑循环和勃起的生理调节中发挥重要作用。在本研究中，氮能神经功能的变化进行了检查，在阴茎海绵体分离的实验模型大鼠的生活方式相关的疾病，如SHR的高血压和ZDF大鼠的糖尿病与肥胖。在实验模型大鼠中，平滑肌的神经源性扩张活动由于收缩神经功能亢进或扩张神经功能减退或两者兼而有之而降低。阴茎海绵体中nNOS表达的减少被认为是导致ZDF大鼠勃起功能障碍的原因。

Nitrergic nerves dilating smooth muscles of blood vessels and corpus cavernosum penis play an important role in the physiological regulation of cerebral circulation and erection, respectively. In the present study, change in nitrergic nerve function was examined in the corpus cavernosum isolated from experimental model rats of life style-related diseases such as SHR for hypertension and ZDF rats for diabetes with obese. In the experimental model rats, neurogenic dilating activity of smooth muscles was decreased due to hyperfunction of constricting nerves, hypofunction of dilating nerves, or both. Decreased expression of nNOS in the corpus cavernosum is suggested to cause erectile dysfunction in ZDF rats.