Characterization and clinical application of endogenous Alzheimer's disease-suppressing factor

一种新的阿尔茨海默病(AD)抑制因子EH已经被生物学检测。首先，发现人类脑脊液中的EH浓度为1-5 nm。其次，腹腔注射EH可改善由M胆碱受体阻滞剂东莨菪碱引起的小鼠痴呆。结合上述发现，这些结果表明，EH而不是人在体内作为AD抑制因子发挥着核心作用。此外，AD患者脑脊液中EH浓度明显低于正常对照组。最后发现，EHIbeta抑制分泌到细胞外间隙，而EHIsigma分泌到细胞外间隙，抑制EH活性。

A new Alzheimer's disease (AD)-suppressive factor EH has been biologically examined. First, it was found that EH concentration in the cerebrospinal fluid is 1-5nM in humans. Second, intraperitoneal administration of EH ameliorates dementia of mice, caused by scopolamine, a muscarinic acetylcholine receptor blocker.. Combined with foregoing findings, these results suggest that EH, rather than Humanin, plays a central role in vivo as an AD-suppressive factor.. Furthermore, EH concentrations in the cerebrospinal fluids of AD patients appear to be lower than those of normal controls. Finally, it was found that EHIbeta inhibits secretion of into extracellular space and EHIsigma is secreted into the extracellular space and inhibits EH activity.