Clinical application and expression mechanisms for KL-6/MUC1 having a selectin ligand

DIC（血管内凝血）是严重肺损伤（称为急性呼吸窘迫综合征（ARDS））的重要预后因素。一项回顾性研究表明，具有选择素配体（SLAK）的KL-6/MUC 1可预测ARDS中DIC的发生。SLAK对预测ARDS患者死亡率的敏感性和特异性均优于已知的因素，是一种良好的预后生物标志物。在分子合成机制的研究中，我们证明了KL-6可以在表达人MUC 1的小鼠中表达，尽管KL-6在小鼠中从未表达。我们还证明，KL-6可以在急性肺损伤和博莱霉素肺纤维化的小鼠模型，通过使用这种转基因小鼠的生物标志物。

DIC (blood coagulation occurring in vessels) is an important prognostic factor in a severe lung injury called acute respiratory distress syndrome (ARDS). A retrospective study demonstrated that KL-6/MUC1 having a selectin ligand (SLAK) can predict the onset of DIC in ARDS. The SLAK had the better sensitivity and specificity for prediction of mortality than previously known factors and thus is a good prognostic biomarker in ARDS. During investigation on the mechanism for the synthesis of the molecules, we demonstrated that KL-6 could be expressed in mice expressing the human MUC1, although KL-6 is never expressed in mice. We also demonstrated that KL-6 could be a biomarker in mouse models of acute lung injury and bleomycin pulmonary fibrosis by using this transgenic mouse.