Physiological substrate of beta cell autophagy

2型糖尿病是世界范围内严重的健康问题。在这项研究中，为了揭示2型糖尿病中观察到的β细胞的病理生理学，我们研究了自噬失败在人胰岛淀粉样多肽（hIAPP）毒性中的作用。对敲除小鼠的详细分析表明，自噬失败使胰岛素抵抗条件下hIAPP的β细胞毒性恶化。这些数据提示自噬失败可能参与了2型糖尿病β细胞衰竭的发病机制。

Type2 diabetes mellitus is a serious health problem in the world. In this study, to uncover the pathophisiology of beta cells observed in type 2 diabetes mellitus, we investigated the role of autophagy failure on the human islet amyloid polypeptide (hIAPP) toxicity. Detailed analyses using knock-out mices revealed that autophagy failure deteriorats beta cell toxicity of hIAPP under insulin resistance condition. These data suggest that autophagy failure may be involved in the pathogenesis of beta cell failure in type 2 diabetes.