Roles of Lutheran in tumor cell adhesion and migration

Lutheran（Lu）是一种免疫球蛋白超家族跨膜受体，也被称为基底细胞粘附分子（B-CAM）。Lu/B-CAM是层粘连蛋白α 5的特异性受体，层粘连蛋白α 5是层粘连蛋白-511的亚基，层粘连蛋白-511是各种组织中基底膜的主要组分。因此，Lu/B-CAM和层粘连蛋白α 5之间的相互作用可能涉及肿瘤细胞的侵袭和转移。在这项研究中，我们发现了抑制Lu/B-CAM与层粘连蛋白α 5结合的抗体，并提供了层粘连蛋白-511上肿瘤细胞迁移的机制。我们还表明，Lu/B-CAM从细胞表面释放是一个候选的标志物肝细胞癌。

Lutheran (Lu), an immunoglobulin superfamily transmembrane receptor, is also known as basal cell adhesion molecule (B-CAM). Lu/B-CAM is a specific receptor for laminin alpha5, a subunit of laminin-511 that is a major component of basement membranes in various tissues. Therefore it is likely that the interaction between Lu/B-CAM and laminin alpha5 involves in tumor cell invasion and metastasis. In this study we discovered an antibody that inhibited the binding of Lu/B-CAM to laminin alpha5 and provided mechanistic insight in tumor cell migration on laminin-511. We also showed that Lu/B-CAM released from cell surface was a candidate marker for hepatocellular carcinoma.