The elucidation of oxidation mechanism of a DNA base and search of the highly bioavailable antioxidants

DNA中8-氧鸟苷的氧化形成与包括癌症在内的退行性疾病的诱导密切相关。然而，其内源性氧化剂尚不清楚。本研究表明，内源性氧化剂是在线粒体膜等生物膜中产生的脂质氢过氧化物，而不是传统认识的过氧化氢。此外，研究发现脂溶性抗氧化剂能够抑制8-氧鸟苷的形成。因此，蔬菜、水果和茶叶中含有的脂溶性抗氧化剂，如叶黄素、虾青素和儿茶酚类黄酮、槲皮素和石黄素，可以预防退行性疾病的形成。

The oxidative formation of 8-oxo-guanosine in DNA is closely associated with the induction of degenerative diseases, including cancer. However, its endogenous oxidant is unclear. The present study showed that the endogenous oxidant was lipid hydroperoxides generating in biomembrane such as mitochondrial membrane, but was not hydrogen peroxide that had been recognized conventionally. Also, the study found that lipid-soluble antioxidants were able to suppress the formation of 8-oxo-guanosine. Thus, vegetables, fruits and tea including the lipid-soluble antioxidants such as xanthophyll astaxanthin and catechol flavonoids, quercetin and liteorin, can prevent form degenerative diseases.