Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytes

诺必列汀是一种来自柑橘皮的多甲氧基化黄酮，具有广泛的药理活性。在这项研究中，我们研究了诺贝尔对人表皮角质形成细胞分化的影响。本文研究了几种柑桔多甲氧基黄酮类化合物对诱导分化的影响。我们目前的研究结果表明，B环上的两个甲氧基的存在似乎是分化诱导作用的关键。此外，本实验结果还为ERK/CREB信号通路的激活在一定程度上介导了诺贝尔碱诱导的人表皮角质形成细胞分化的改善提供了可能的证据。此外，本实验还评价了诺贝尔碱局部应用对胶带剥离破坏表皮屏障后表皮屏障恢复率的影响。胶带剥离后立即，nobiloxane加速无毛小鼠皮肤上的屏障恢复。

Nobiletin, a polymethoxylated flavone from citrus peels, is known to have a wide range of pharmacological activities. In this study, we examined the effects of nobiletin on differentiation of human epidermal keratinocytes. We examined the effects of several polymethoxyl flavones of Citrus on induction of differentiaon. Our present findings suggest that the presence of two methoxyl groups on the B ring appears to be critical for the differentiation-inducing effect. In addition, the results obtained here provide possible evidence that the activation of ERK/CREB signaling in part mediates improvement of differentiation of human epidermal keratinocytes induces by nobiletin.Furthermore, the effects of topical application of nobiletin on the epidermal barrier recovery rate after barrier disruption by tape stripping were evaluated. Immediately after tape stripping, nobiletin accelerated the barrier recovery on hairless mouse skin.