Protein tyrosine phosphorylation in the neurovascular unit in cerebrovascular disease and therapeutic strategies

本研究旨在确定蛋白酪氨酸磷酸化在脑卒中后神经血管单元中的作用。本研究表明卒中后周围脑毛细血管中mpo阳性细胞增多，提示中性粒细胞浸润。src抑制剂抑制了这种浸润。src抑制剂也减弱了NOX亚基p67phox和COX-2水平的升高。此外，本研究提示卒中后血脑屏障的病理生理改变可能受周细胞pdgfr - β酪氨酸磷酸化的调节。

This study sought to determine the role of protein tyrosine phosphorylation in the neurovascular unit after stroke. This study demonstrated that MPO-positive cells were increased in the surrounding brain capillaries after stroke, suggesting neutrophil infiltration. This infiltration was inhibited by src inhibitor. The increases in the levels of NOX subunit p67phox and COX-2 were also attenuated by src inhibitor. In addition, this study suggests that the pathophysiological alteration of the blood brain barrier after stroke may be regulated by tyrosine phosphorylation of PDGFR-beta in the pericytes.