Synthesis of new compounds inducing potent and selective differentiation from neural stem cells into neurons

我们合成了新的化合物，这些化合物在体外具有从神经前体细胞向神经元选择性分化的活性。测定结果表明，在欧米伽末端引入间甲苯基的维生素K类似物的活性最强，是对照的两倍。这一发现表明，通过对维生素K进行修饰，有可能获得更有效的化合物。现在，我们将对这些化合物的作用机理进行研究。

We synthesized new compounds, which have selective differentiation activity from neuronal progenitor cells into neurons in vitro. The result of the assay exhibited vitamin K analogues introduced m-methylphenyl group at the omega-terminal position had the most potent activity, which was twice as much as control. This finding indicated that it will be possible to obtain much more potent compounds with modification of vitamin K. Now we are going to investigate the functional mechanism of the compounds.