Effect of troponin C affinity for Ca2+ on the frequency of arrhythmias

在心肌中，肌丝对钙离子的亲和力决定了钙波的传播速度。同样，在衰弱的肌肉中，它们亲和力的增加也加快了传播速度。在局部[K+]o增加的肌肉中，由于肌肉收缩不均匀，它们的亲和力增加，从而加快了传播速度。这些结果表明，肌丝的亲和力是室性心律失常发生和频率的重要决定因素，可能是通过改变钙波的速度来实现的。

In cardiac ventricular muscle, the affinity of the myofilaments for Ca2+ determined the propagation velocity of Ca2+ waves. Also in the failing muscle, an increase in their affinity increased the propagation velocity. In the muscle with a regional increase in [K+]o, the increase in their affinity due to nonuniform muscle contraction increased the propagation velocity. These results suggest that the affinity of the myofilaments is an important determinant for the initiation and the frequency of ventricular arrhythmias probably by changing the velocity of Ca2+ waves.