Effect of dephosphorylation of troponin I on arrhythmogenesis in failing hearts

肌钙蛋白 I 去磷酸化对衰竭心脏心律失常的影响

• 批准号: 20590205
• 负责人: MIURA Masahito
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590205/
• 关键词: 病態生理; カルシウム; 心不全; トロポニンC

An increase in the affinity of the myofilaments for Ca^<2+> by lengthening the muscle or applying a Ca^<2+> sensitizer for myofilaments sustained triggered arrhythmias and increased their frequency in intact cardiac muscle. In failing hearts, dephosphorylation of troponin-I and an increase in Ca^<2+> sensitivity of the sarcoplasmic reticulum Ca^<2+> release channel increased the velocity of Ca^<2+> 2+ waves and the amplitude of delayed afterdepolarizations, thereby causing arrhythmogenesis. The affinity of the myofilaments for Ca^<2+> plays an important role in the occurrence of arrhythmias.

通过延长肌肉或应用Ca^<2+>致敏剂，肌丝对Ca^<2+>的亲和力增加，持续触发心律失常，并增加其在完整心肌中的频率。在衰竭心脏中，肌钙蛋白- 1的去磷酸化和肌浆网Ca^<2+>释放通道Ca^<2+>敏感性的增加增加了Ca^<2+> 2+波的速度和延迟后去极化的幅度，从而引起心律失常。肌丝对Ca^<2+>的亲和力在心律失常的发生中起重要作用。

项目成果

Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic-delayed afterdepolarizations in rat cardiac muscle

• DOI: 10.1093/cvr/cvn162
• 发表时间: 2008-10-01
• 期刊: CARDIOVASCULAR RESEARCH
• 影响因子: 10.8
• 作者: Miura, Masahito;Wakayama, Yuji;Shimokawa, Hiroaki
• 通讯作者: Shimokawa, Hiroaki

Regional Increase in Extracellular Potassium Can Be Arrhythmogenic by Non-uniform Muscle Contraction in Rat Cardiac Muscle

大鼠心肌细胞外钾的区域性增加可能因肌肉收缩不均匀而致心律失常

• 发表时间: 2010
• 作者: Taiki Hattori;Masahito Miura;Naomi Murai;Chiyohiko Shindoh
• 通讯作者: Chiyohiko Shindoh

Non-uniform Muscle Contraction Sustains and Facilitates Triggered Arrhythmias in Rat Cardiac Muscle

不均匀的肌肉收缩维持并促进大鼠心肌触发的心律失常

• 发表时间: 2009
• 作者: Taichi Nishio;Masahito Miura;Taiki Hattori;Naomi Murai;Chiyohiko Shindoh
• 通讯作者: Chiyohiko Shindoh

Tulobuterol Patch Maintains Diaphragm Muscle Contractility for Over Twenty-four Hours in a Mouse Model of Sepsis

• DOI: 10.1620/tjem.218.271
• 发表时间: 2009-08-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Shindoh, Chiyohiko;Murakami, Yoshie;Miura, Masahito
• 通讯作者: Miura, Masahito

Maintenance of Triggered Arrhythmias by Non-uniform Excitation-Contraction Coupling in Rat Cardiac Muscle

大鼠心肌不均匀兴奋-收缩耦合引发的心律失常的维持

• 发表时间: 2008
• 作者: Masahito Miura;Taichi Nishio;Chiyohiko Shindoh;Hiroaki Shimokawa
• 通讯作者: Hiroaki Shimokawa