Possible Involvement of ion Channels in atrial fibrillation

瞬时受体电位（TRP）通道的研究，显着扩展了我们的知识，关于心肌细胞中的Ca 2+信号的分子基础。心脏TRP通道的功能意义可能与膜电位的改变或Ca2+进入非收缩室有关，在非收缩室中诱导引起各种心脏疾病的基因表达。这项研究强调了TRP通道在心脏疾病中预期作用的一些方面。有证据表明，（a）TRPC 1、TRPC 3或TRPC 6的活性增加参与心脏肥大的发展，其中这些TRPC通道作为广泛的肥大刺激的独特传感器，和（B）TRPM 4，7和TRPC 3，6的活性增加参与心房重构或心律失常的机械牵张。最终，TRP通道可能成为治疗人类心脏疾病的新的药理学靶点。

Studies of transient receptor potential (TRP) channels have significantly extended our knowledge regarding the molecular basis of Ca2+ signals in cardiac myocytes. The functional significance of cardiac TRP channels is likely connected to the alteration of membrane potential or Ca2+ entry into a noncontractile compartment, where gene expression responsible for various cardiac diseases is induced. This study highlights some aspects of TRP channels with anticipated roles in cardiac disease. Evidence suggests that (a) increased activities of TRPC1, TRPC3, or TRPC6 are involved in the development of cardiac hypertrophy, where these TRPC channels act as unique sensors for a wide range of hypertrophic stimuli, and (b) increased activities of TRPM4,7 and TRPC3,6 are involved in atrial remodeling or mechanical stretch on cardiac arrhythmia. Ultimately, TRP channels may become novel pharmacological targets in the treatment of human cardiac disease.