Elucidation of abnormalities of neurogenesis and brain niche in stress-related disorders

GPR56siRNA显著抑制小鼠诱导的多能干细胞(iPS细胞)的神经分化。然而，GPR56 siRNA的转染并不影响小鼠神经前体细胞的纤维连接蛋白结合活性。β-肾上腺素受体或5-羟色胺受体刺激可显著促进小鼠iPS细胞的神经分化，但不影响小鼠神经前体细胞的纤维连接蛋白结合活性。这些发现提示GPR56、β-肾上腺素受体和5-羟色胺受体参与了神经分化。

Transfection of GPR56 siRNA significantly inhibited neural diffrentiation of mouse induced pluripotent stem cells (iPS cells). However, the transfection of GPR56 siRNA did not affect fibronectin-binding activity in mouse neural progenitor cells. Stimulation with either beta-adrenoceptor or serotonin receptor significantly enhanced neural differentiation of mouse iPS cells, but the stimulation did not affect fibronectin-binding activity in mouse neural progenitor cells. These findings suggest the involvement of GPR56, beta-adrenoceptor, and serotonin receptor on neural differentiation.