Interaction of cognitive function and glucose metabolism -angiotenisn IV and IRAP system as a new therapeutic target-

我之前研究的澳大利亚实验室克隆了胰岛素调节的氨基肽酶（IRAP）作为血管紧张素IV的受体，血管紧张素IV是肾素-血管紧张素系统的子成分。它是锌依赖性膜氨肽酶家族的成员，主要位于海马，在GLUT 4的膜转位中起重要作用。我们报道了另一个亚组分，血管紧张素（1-7）通过增加MEF 1和GLUT 4的产生来改善葡萄糖耐受不良。我们计划血管紧张素IV和IRAP作为一个新的治疗目标，认知障碍使用淀粉样蛋白β 1-40脑室内输注模型与IRAP基因敲除小鼠捐赠的澳大利亚实验室。该模型的认知功能太不稳定，无法评估血管紧张素IV和IRAP对认知障碍的作用，我们现在计划用IRAP和APP制造双敲除小鼠。

The Australian laboratory which I investigated before cloned the insulin-regulated aminopeptidase (IRAP) as a receptor for angiotensin IV, sub-component of renin-angiotensin system. It is a member of the family of zinc- dependent membrane aminopeptidases, which is mainly located in hippocampus and plays an important role for translocation to membrane of GLUT4. We reported another sub-component, angiotensin (1-7) improved glucose intolerance via increased MEF1 and GLUT4 production. We planned angiotensin IV and IRAP as a new therapeutic target for cognitive impairment using amyloid beta 1-40 intra-ventricular infusion model with IRAP knockout mice donated from the Australian laboratory. The cognitive function of this model is too unstable to evaluate angiotensin IV and IRAP function for cognitive impairment, we are now planning to make double knockout mice with IRAP and APP.